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- Title
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.
- Authors
Thye, Thorsten; Vannberg, Fredrik O; Wong, Sunny H; Owusu-Dabo, Ellis; Osei, Ivy; Gyapong, John; Sirugo, Giorgio; Sisay-Joof, Fatou; Enimil, Anthony; Chinbuah, Margaret A; Floyd, Sian; Warndorff, David K; Sichali, Lifted; Malema, Simon; Crampin, Amelia C; Ngwira, Bagrey; Teo, Yik Y; Small, Kerrin; Rockett, Kirk; Kwiatkowski, Dominic; Fine, Paul E; Hill, Philip C; Newport, Melanie; Lienhardt, Christian; Adegbola, Richard A; Corrah, Tumani; Ziegler, Andreas; Morris, Andrew P; Meyer, Christian G; Horstmann, Rolf D; Hill, Adrian V S; African TB Genetics Consortium; Wellcome Trust Case Control Consortium
- Abstract
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
- Publication
Nature genetics, 2010, Vol 42, Issue 9, p739
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.639