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- Title
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.
- Authors
Xiangdong Liu; Invernizzi, Pietro; Yue Lu; Kosoy, Roman; Yan Lu; Bianchi, Ilaria; Podda, Mauro; Chun Xu; Gang Xie; Macciardi, Fabio; Selmi, Carlo; Lupoli, Sara; Shigeta, Russell; Ransom, Michael; Lleo, Ana; Lee, Annette T.; Mason, Andrew L.; Myers, Robert P.; Peltekian, Kevork M.; Ghent, Cameron N.
- Abstract
A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).
- Publication
Nature Genetics, 2010, Vol 42, Issue 8, p658
- ISSN
1061-4036
- Publication type
Academic Journal
- DOI
10.1038/ng.627