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- Title
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.
- Authors
Nikoloski, Gorica; Langemeijer, Saskia M C; Kuiper, Roland P; Knops, Ruth; Massop, Marion; Tönnissen, Evelyn R L T M; van der Heijden, Adrian; Scheele, Theresia N; Vandenberghe, Peter; de Witte, Theo; van der Reijden, Bert A; Jansen, Joop H
- Abstract
In myelodysplastic syndromes (MDS), deletions of chromosome 7 or 7q are common and correlate with a poor prognosis. The relevant genes on chromosome 7 are unknown. We report here that EZH2, located at 7q36.1, is frequently targeted in MDS. Analysis of EZH2 deletions, missense and frameshift mutations strongly suggests that EZH2 is a tumor suppressor. As EZH2 functions as a histone methyltransferase, abnormal histone modification may contribute to epigenetic deregulation in MDS.
- Publication
Nature genetics, 2010, Vol 42, Issue 8, p665
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.620