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- Title
Common variants in FOXP1 are associated with generalized vitiligo.
- Authors
Ying Jin; Birlea, Stanca A; Fain, Pamela R; Mailloux, Christina M; Riccardi, Sheri L; Gowan, Katherine; Holland, Paulene J; Bennett, Dorothy C; Wallace, Margaret R; McCormack, Wayne T; Kemp, E Helen; Gawkrodger, David J; Weetman, Anthony P; Picardo, Mauro; Leone, Giovanni; Taïeb, Alain; Jouary, Thomas; Ezzedine, Khaled; van Geel, Nanny; Lambert, Jo
- Abstract
In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7).
- Publication
Nature Genetics, 2010, Vol 42, Issue 7, p576
- ISSN
1061-4036
- Publication type
Academic Journal
- DOI
10.1038/ng.602