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- Title
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
- Authors
Petersen, Gloria M; Amundadottir, Laufey; Fuchs, Charles S; Kraft, Peter; Stolzenberg-Solomon, Rachael Z; Jacobs, Kevin B; Arslan, Alan A; Bueno-de-Mesquita, H Bas; Gallinger, Steven; Gross, Myron; Helzlsouer, Kathy; Holly, Elizabeth A; Jacobs, Eric J; Klein, Alison P; LaCroix, Andrea; Li, Donghui; Mandelson, Margaret T; Olson, Sara H; Risch, Harvey A; Zheng, Wei; Albanes, Demetrius; Bamlet, William R; Berg, Christine D; Boutron-Ruault, Marie-Christine; Buring, Julie E; Bracci, Paige M; Canzian, Federico; Clipp, Sandra; Cotterchio, Michelle; de Andrade, Mariza; Duell, Eric J; Gaziano, J Michael; Giovannucci, Edward L; Goggins, Michael; Hallmans, Göran; Hankinson, Susan E; Hassan, Manal; Howard, Barbara; Hunter, David J; Hutchinson, Amy; Jenab, Mazda; Kaaks, Rudolf; Kooperberg, Charles; Krogh, Vittorio; Kurtz, Robert C; Lynch, Shannon M; McWilliams, Robert R; Mendelsohn, Julie B; Michaud, Dominique S; Parikh, Hemang; Patel, Alpa V; Peeters, Petra H M; Rajkovic, Aleksandar; Riboli, Elio; Rodriguez, Laudina; Seminara, Daniela; Shu, Xiao-Ou; Thomas, Gilles; Tjønneland, Anne; Tobias, Geoffrey S; Trichopoulos, Dimitrios; Van Den Eeden, Stephen K; Virtamo, Jarmo; Wactawski-Wende, Jean; Wang, Zhaoming; Wolpin, Brian M; Yu, Herbert; Yu, Kai; Zeleniuch-Jacquotte, Anne; Fraumeni, Joseph F, Jr; Hoover, Robert N; Hartge, Patricia; Chanock, Stephen J
- Abstract
We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.
- Publication
Nature genetics, 2010, Vol 42, Issue 3, p224
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.522