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- Title
Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
- Authors
Skibola, Christine F; Bracci, Paige M; Halperin, Eran; Conde, Lucia; Craig, David W; Agana, Luz; Iyadurai, Kelly; Becker, Nikolaus; Brooks-Wilson, Angela; Curry, John D; Spinelli, John J; Holly, Elizabeth A; Riby, Jacques; Zhang, Luoping; Nieters, Alexandra; Smith, Martyn T; Brown, Kevin M
- Abstract
We conducted genome-wide association studies of non-Hodgkin lymphoma using Illumina HumanHap550 BeadChips to identify subtype-specific associations in follicular, diffuse large B-cell and chronic lymphocytic leukemia/small lymphocytic lymphomas. We found that rs6457327 on 6p21.33 was associated with susceptibility to follicular lymphoma (FL; N = 189 cases, 592 controls) with validation in another 456 FL cases and 2,785 controls (combined allelic P = 4.7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1).
- Publication
Nature genetics, 2009, Vol 41, Issue 8, p873
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.419