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- Title
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
- Authors
Benjamin, Emelia J; Rice, Kenneth M; Arking, Dan E; Pfeufer, Arne; van Noord, Charlotte; Smith, Albert V; Schnabel, Renate B; Bis, Joshua C; Boerwinkle, Eric; Sinner, Moritz F; Dehghan, Abbas; Lubitz, Steven A; D'Agostino, Ralph B, Sr; Lumley, Thomas; Ehret, Georg B; Heeringa, Jan; Aspelund, Thor; Newton-Cheh, Christopher; Larson, Martin G; Marciante, Kristin D; Soliman, Elsayed Z; Rivadeneira, Fernando; Wang, Thomas J; Eiríksdottir, Gudny; Levy, Daniel; Psaty, Bruce M; Li, Man; Chamberlain, Alanna M; Hofman, Albert; Vasan, Ramachandran S; Harris, Tamara B; Rotter, Jerome I; Kao, W H Linda; Agarwal, Sunil K; Stricker, Bruno H Ch; Wang, Ke; Launer, Lenore J; Smith, Nicholas L; Chakravarti, Aravinda; Uitterlinden, André G; Wolf, Philip A; Sotoodehnia, Nona; Köttgen, Anna; van Duijn, Cornelia M; Meitinger, Thomas; Mueller, Martina; Perz, Siegfried; Steinbeck, Gerhard; Wichmann, H-Erich; Lunetta, Kathryn L; Heckbert, Susan R; Gudnason, Vilmundur; Alonso, Alvaro; Kääb, Stefan; Ellinor, Patrick T; Witteman, Jacqueline C M
- Abstract
We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
- Publication
Nature genetics, 2009, Vol 41, Issue 8, p879
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.416