We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome-wide association study identifies five susceptibility loci for glioma.
- Authors
Shete, Sanjay; Hosking, Fay J; Robertson, Lindsay B; Dobbins, Sara E; Sanson, Marc; Malmer, Beatrice; Simon, Matthias; Marie, Yannick; Boisselier, Blandine; Delattre, Jean-Yves; Hoang-Xuan, Khe; El Hallani, Soufiane; Idbaih, Ahmed; Zelenika, Diana; Andersson, Ulrika; Henriksson, Roger; Bergenheim, A Tommy; Feychting, Maria; Lönn, Stefan; Ahlbom, Anders; Schramm, Johannes; Linnebank, Michael; Hemminki, Kari; Kumar, Rajiv; Hepworth, Sarah J; Price, Amy; Armstrong, Georgina; Liu, Yanhong; Gu, Xiangjun; Yu, Robert; Lau, Ching; Schoemaker, Minouk; Muir, Kenneth; Swerdlow, Anthony; Lathrop, Mark; Bondy, Melissa; Houlston, Richard S
- Abstract
To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
- Publication
Nature genetics, 2009, Vol 41, Issue 8, p899
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.407