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- Title
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
- Authors
Pomerantz, Mark M; Ahmadiyeh, Nasim; Jia, Li; Herman, Paula; Verzi, Michael P; Doddapaneni, Harshavardhan; Beckwith, Christine A; Chan, Jennifer A; Hills, Adam; Davis, Matt; Yao, Keluo; Kehoe, Sarah M; Lenz, Heinz-Josef; Haiman, Christopher A; Yan, Chunli; Henderson, Brian E; Frenkel, Baruch; Barretina, Jordi; Bass, Adam; Tabernero, Josep; Baselga, José; Regan, Meredith M; Manak, J Robert; Shivdasani, Ramesh; Coetzee, Gerhard A; Freedman, Matthew L
- Abstract
An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene. These data provide strong support for a biological mechanism underlying this non-protein-coding risk variant.
- Publication
Nature genetics, 2009, Vol 41, Issue 8, p882
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.403