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- Title
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
- Authors
Stolk, Lisette; Zhai, Guangju; van Meurs, Joyce B J; Verbiest, Michael M P J; Visser, Jenny A; Estrada, Karol; Rivadeneira, Fernando; Williams, Frances M; Cherkas, Lynn; Deloukas, Panos; Soranzo, Nicole; de Keyzer, Jules J; Pop, Victor J M; Lips, Paul; Lebrun, Corinne E I; van der Schouw, Yvonne T; Grobbee, Diederick E; Witteman, Jacqueline; Hofman, Albert; Pols, Huibert A P; Laven, Joop S E; Spector, Tim D; Uitterlinden, André G
- Abstract
We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10(-11)), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10(-11)) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.
- Publication
Nature genetics, 2009, Vol 41, Issue 6, p645
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.387