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- Title
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
- Authors
Perry, John R B; Stolk, Lisette; Franceschini, Nora; Lunetta, Kathryn L; Zhai, Guangju; McArdle, Patrick F; Smith, Albert V; Aspelund, Thor; Bandinelli, Stefania; Boerwinkle, Eric; Cherkas, Lynn; Eiriksdottir, Gudny; Estrada, Karol; Ferrucci, Luigi; Folsom, Aaron R; Garcia, Melissa; Gudnason, Vilmundur; Hofman, Albert; Karasik, David; Kiel, Douglas P; Launer, Lenore J; van Meurs, Joyce; Nalls, Michael A; Rivadeneira, Fernando; Shuldiner, Alan R; Singleton, Andrew; Soranzo, Nicole; Tanaka, Toshiko; Visser, Jenny A; Weedon, Michael N; Wilson, Scott G; Zhuang, Vivian; Streeten, Elizabeth A; Harris, Tamara B; Murray, Anna; Spector, Tim D; Demerath, Ellen W; Uitterlinden, André G; Murabito, Joanne M
- Abstract
We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10(-9)), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10(-9)), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation.
- Publication
Nature genetics, 2009, Vol 41, Issue 6, p648
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.386