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- Title
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
- Authors
King, Jennifer C; Xu, Jin; Wongvipat, John; Hieronymus, Haley; Carver, Brett S; Leung, David H; Taylor, Barry S; Sander, Chris; Cardiff, Robert D; Couto, Suzana S; Gerald, William L; Sawyers, Charles L
- Abstract
The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.
- Publication
Nature genetics, 2009, Vol 41, Issue 5, p524
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.371