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- Title
Human mutation rate associated with DNA replication timing.
- Authors
Stamatoyannopoulos, John A; Adzhubei, Ivan; Thurman, Robert E; Kryukov, Gregory V; Mirkin, Sergei M; Sunyaev, Shamil R
- Abstract
Eukaryotic DNA replication is highly stratified, with different genomic regions shown to replicate at characteristic times during S phase. Here we observe that mutation rate, as reflected in recent evolutionary divergence and human nucleotide diversity, is markedly increased in later-replicating regions of the human genome. All classes of substitutions are affected, suggesting a generalized mechanism involving replication time-dependent DNA damage. This correlation between mutation rate and regionally stratified replication timing may have substantial evolutionary implications.
- Publication
Nature genetics, 2009, Vol 41, Issue 4, p393
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.363