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- Title
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
- Authors
Palavalli, Lavanya H; Prickett, Todd D; Wunderlich, John R; Wei, Xiaomu; Burrell, Allison S; Porter-Gill, Patricia; Davis, Sean; Wang, Chenwei; Cronin, Julia C; Agrawal, Neena S; Lin, Jimmy C; Westbroek, Wendy; Hoogstraten-Miller, Shelley; Molinolo, Alfredo A; Fetsch, Patricia; Filie, Armando C; O'Connell, Michael P; Banister, Carolyn E; Howard, Jason D; Buckhaults, Phillip; Weeraratna, Ashani T; Brody, Lawrence C; Rosenberg, Steven A; Samuels, Yardena
- Abstract
A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.
- Publication
Nature genetics, 2009, Vol 41, Issue 5, p518
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.340