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- Title
Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep.
- Authors
Harbison, Susan T; Carbone, Mary Anna; Ayroles, Julien F; Stone, Eric A; Lyman, Richard F; Mackay, Trudy F C
- Abstract
Sleep disorders are common in humans, and sleep loss increases the risk of obesity and diabetes. Studies in Drosophila have revealed molecular pathways and neural tissues regulating sleep; however, genes that maintain genetic variation for sleep in natural populations are unknown. Here, we characterized sleep in 40 wild-derived Drosophila lines and observed abundant genetic variation in sleep architecture. We associated sleep with genome-wide variation in gene expression to identify candidate genes. We independently confirmed that molecular polymorphisms in Catsup (Catecholamines up) are associated with variation in sleep and that P-element mutations in four candidate genes affect sleep and gene expression. Transcripts associated with sleep grouped into biologically plausible genetically correlated transcriptional modules. We confirmed co-regulated gene expression using P-element mutants. Quantitative genetic analysis of natural phenotypic variation is an efficient method for revealing candidate genes and pathways.
- Publication
Nature genetics, 2009, Vol 41, Issue 3, p371
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.330