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- Title
Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
- Authors
Stefansson, Hreinn; Steinberg, Stacy; Petursson, Hjorvar; Gustafsson, Omar; Gudjonsdottir, Iris H; Jonsdottir, Gudrun A; Palsson, Stefan T; Jonsson, Thorlakur; Saemundsdottir, Jona; Bjornsdottir, Gyda; Böttcher, Yvonne; Thorlacius, Theodora; Haubenberger, Dietrich; Zimprich, Alexander; Auff, Eduard; Hotzy, Christoph; Testa, Claudia M; Miyatake, Lisa A; Rosen, Ami R; Kristleifsson, Kristleifur; Rye, David; Asmus, Friedrich; Schöls, Ludger; Dichgans, Martin; Jakobsson, Finnbogi; Benedikz, John; Thorsteinsdottir, Unnur; Gulcher, Jeffrey; Kong, Augustine; Stefansson, Kari
- Abstract
We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]
- Publication
Nature genetics, 2009, Vol 41, Issue 3, p277
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.299