We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome-wide association study identifies two susceptibility loci for osteosarcoma.
- Authors
Savage, Sharon A; Mirabello, Lisa; Wang, Zhaoming; Gastier-Foster, Julie M; Gorlick, Richard; Khanna, Chand; Flanagan, Adrienne M; Tirabosco, Roberto; Andrulis, Irene L; Wunder, Jay S; Gokgoz, Nalan; Patiño-Garcia, Ana; Sierrasesúmaga, Luis; Lecanda, Fernando; Kurucu, Nilgün; Ilhan, Inci Ergurhan; Sari, Neriman; Serra, Massimo; Hattinger, Claudia; Picci, Piero; Spector, Logan G; Barkauskas, Donald A; Marina, Neyssa; de Toledo, Silvia Regina Caminada; Petrilli, Antonio S; Amary, Maria Fernanda; Halai, Dina; Thomas, David M; Douglass, Chester; Meltzer, Paul S; Jacobs, Kevin; Chung, Charles C; Berndt, Sonja I; Purdue, Mark P; Caporaso, Neil E; Tucker, Margaret; Rothman, Nathaniel; Landi, Maria Teresa; Silverman, Debra T; Kraft, Peter; Hunter, David J; Malats, Nuria; Kogevinas, Manolis; Wacholder, Sholom; Troisi, Rebecca; Helman, Lee; Fraumeni, Joseph F, Jr; Yeager, Meredith; Hoover, Robert N; Chanock, Stephen J
- Abstract
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10⁻⁹) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.
- Publication
Nature genetics, 2013, Vol 45, Issue 7, p799
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.2645