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- Title
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.
- Authors
Xu, Jianfeng; Mo, Zengnan; Ye, Dingwei; Wang, Meilin; Liu, Fang; Jin, Guangfu; Xu, Chuanliang; Wang, Xiang; Shao, Qiang; Chen, Zhiwen; Tao, Zhihua; Qi, Jun; Zhou, Fangjian; Wang, Zhong; Fu, Yaowen; He, Dalin; Wei, Qiang; Guo, Jianming; Wu, Denglong; Gao, Xin; Yuan, Jianlin; Wang, Gongxian; Xu, Yong; Wang, Guozeng; Yao, Haijun; Dong, Pei; Jiao, Yang; Shen, Mo; Yang, Jin; Ou-Yang, Jun; Jiang, Haowen; Zhu, Yao; Ren, Shancheng; Zhang, Zhengdong; Yin, Changjun; Gao, Xu; Dai, Bo; Hu, Zhibin; Yang, Yajun; Wu, Qijun; Chen, Hongyan; Peng, Peng; Zheng, Ying; Zheng, Xiaodong; Xiang, Yongbing; Long, Jirong; Gong, Jian; Na, Rong; Lin, Xiaoling; Yu, Hongjie; Wang, Zhong; Tao, Sha; Feng, Junjie; Sun, Jishan; Liu, Wennuan; Hsing, Ann; Rao, Jianyu; Ding, Qiang; Wiklund, Fredirik; Gronberg, Henrik; Shu, Xiao-Ou; Zheng, Wei; Shen, Hongbing; Jin, Li; Shi, Rong; Lu, Daru; Zhang, Xuejun; Sun, Jielin; Zheng, S Lilly; Sun, Yinghao
- Abstract
Prostate cancer risk-associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk-associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10(-14)) and 19q13.4 (rs103294, P = 5.34 × 10(-16)) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3, a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells (P < 1 × 10(-4)). These findings may advance the understanding of genetic susceptibility to prostate cancer.
- Publication
Nature genetics, 2012, Vol 44, Issue 11, p1231
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.2424