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- Title
Mouse ooplasm confers context-specific reprogramming capacity.
- Authors
Chan, Michelle M; Smith, Zachary D; Egli, Dieter; Regev, Aviv; Meissner, Alexander
- Abstract
Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes.
- Publication
Nature genetics, 2012, Vol 44, Issue 9, p978
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.2382