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- Title
Structure and function of a transcriptional network activated by the MAPK Hog1.
- Authors
Capaldi, Andrew P; Kaplan, Tommy; Liu, Ying; Habib, Naomi; Regev, Aviv; Friedman, Nir; O'Shea, Erin K
- Abstract
Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.
- Publication
Nature genetics, 2008, Vol 40, Issue 11, p1300
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.235