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- Title
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
- Authors
Di Bernardo, Maria Chiara; Crowther-Swanepoel, Dalemari; Broderick, Peter; Webb, Emily; Sellick, Gabrielle; Wild, Ruth; Sullivan, Kate; Vijayakrishnan, Jayaram; Wang, Yufei; Pittman, Alan M; Sunter, Nicola J; Hall, Andrew G; Dyer, Martin J S; Matutes, Estella; Dearden, Claire; Mainou-Fowler, Tryfonia; Jackson, Graham H; Summerfield, Geoffrey; Harris, Robert J; Pettitt, Andrew R; Hillmen, Peter; Allsup, David J; Bailey, James R; Pratt, Guy; Pepper, Chris; Fegan, Chris; Allan, James M; Catovsky, Daniel; Houlston, Richard S
- Abstract
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.
- Publication
Nature genetics, 2008, Vol 40, Issue 10, p1204
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.219