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- Title
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
- Authors
Manuel A. R. Ferreira1,2,3,4,5,6; Michael C. O'Donovan; Yan A. Meng1,2,3,4,5; Ian R. Jones; Douglas M. Ruderfer1,3,4,5; Lisa Jones; Jinbo Fan; George Kirov; Roy H. Perlis1,2,3,4,5; Elaine K. Green; Jordan W. Smoller; Detelina Grozeva; Jennifer Stone1,2,3,4,5; Ivan Nikolov; Kimberly Chambert; Marian L. Hamshere; Vishwajit L. Nimgaonkar; Valentina Moskvina; Michael E. Thase; Sian Caesar
- Abstract
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10−9) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 × 10−8, rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.
- Publication
Nature Genetics, 2008, Vol 40, Issue 9, p1056
- ISSN
1061-4036
- Publication type
Academic Journal
- DOI
10.1038/ng.209