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- Title
Ultraconservation identifies a small subset of extremely constrained developmental enhancers.
- Authors
Visel, Axel; Prabhakar, Shyam; Akiyama, Jennifer A; Shoukry, Malak; Lewis, Keith D; Holt, Amy; Plajzer-Frick, Ingrid; Afzal, Veena; Rubin, Edward M; Pennacchio, Len A
- Abstract
Extended perfect human-rodent sequence identity of at least 200 base pairs (ultraconservation) is potentially indicative of evolutionary or functional uniqueness. We used a transgenic mouse assay to compare the embryonic enhancer activity of 231 noncoding ultraconserved human genome regions with that of 206 extremely conserved regions lacking ultraconservation. Developmental enhancers were equally prevalent in both populations, suggesting instead that ultraconservation identifies a small, functionally indistinct subset of similarly constrained cis-regulatory elements.
- Publication
Nature genetics, 2008, Vol 40, Issue 2, p158
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.2007.55