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- Title
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs.
- Authors
Salmon Hillbertz, Nicolette H C; Isaksson, Magnus; Karlsson, Elinor K; Hellmén, Eva; Pielberg, Gerli Rosengren; Savolainen, Peter; Wade, Claire M; von Euler, Henrik; Gustafson, Ulla; Hedhammar, Ake; Nilsson, Mats; Lindblad-Toh, Kerstin; Andersson, Leif; Andersson, Göran
- Abstract
The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.
- Publication
Nature genetics, 2007, Vol 39, Issue 11, p1318
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.2007.4