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- Title
Psoriasis is associated with increased beta-defensin genomic copy number.
- Authors
Hollox, Edward J; Huffmeier, Ulrike; Zeeuwen, Patrick L J M; Palla, Raquel; Lascorz, Jesús; Rodijk-Olthuis, Diana; van de Kerkhof, Peter C M; Traupe, Heiko; de Jongh, Gys; den Heijer, Martin; Reis, André; Armour, John A L; Schalkwijk, Joost
- Abstract
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.
- Publication
Nature genetics, 2008, Vol 40, Issue 1, p23
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.2007.48