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- Title
Efficient mapping of mendelian traits in dogs through genome-wide association.
- Authors
Karlsson, Elinor K; Baranowska, Izabella; Wade, Claire M; Salmon Hillbertz, Nicolette H C; Zody, Michael C; Anderson, Nathan; Biagi, Tara M; Patterson, Nick; Pielberg, Gerli Rosengren; Kulbokas, Edward J, 3rd; Comstock, Kenine E; Keller, Evan T; Mesirov, Jill P; von Euler, Henrik; Kämpe, Olle; Hedhammar, Ake; Lander, Eric S; Andersson, Göran; Andersson, Leif; Lindblad-Toh, Kerstin
- Abstract
With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with approximately 27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only approximately 20 dogs. Specifically, we map two traits with mendelian inheritance: the major white spotting (S) locus and the hair ridge in Rhodesian ridgebacks. For both traits, we map the loci to discrete regions of <1 Mb. Fine-mapping of the S locus in two breeds refines the localization to a region of approximately 100 kb contained within the pigmentation-related gene MITF. Complete sequencing of the white and solid haplotypes identifies candidate regulatory mutations in the melanocyte-specific promoter of MITF. Our results show that genome-wide association mapping within dog breeds, followed by fine-mapping across multiple breeds, will be highly efficient and generally applicable to trait mapping, providing insights into canine and human health.
- Publication
Nature genetics, 2007, Vol 39, Issue 11, p1321
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.2007.10