We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
- Authors
Tenesa, Albert; Farrington, Susan M; Prendergast, James G D; Porteous, Mary E; Walker, Marion; Haq, Naila; Barnetson, Rebecca A; Theodoratou, Evropi; Cetnarskyj, Roseanne; Cartwright, Nicola; Semple, Colin; Clark, Andrew J; Reid, Fiona J L; Smith, Lorna A; Kavoussanakis, Kostas; Koessler, Thibaud; Pharoah, Paul D P; Buch, Stephan; Schafmayer, Clemens; Tepel, Jürgen; Schreiber, Stefan; Völzke, Henry; Schmidt, Carsten O; Hampe, Jochen; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Wilkening, Stefan; Canzian, Federico; Capella, Gabriel; Moreno, Victor; Deary, Ian J; Starr, John M; Tomlinson, Ian P M; Kemp, Zoe; Howarth, Kimberley; Carvajal-Carmona, Luis; Webb, Emily; Broderick, Peter; Vijayakrishnan, Jayaram; Houlston, Richard S; Rennert, Gad; Ballinger, Dennis; Rozek, Laura; Gruber, Stephen B; Matsuda, Koichi; Kidokoro, Tomohide; Nakamura, Yusuke; Zanke, Brent W; Greenwood, Celia M T; Rangrej, Jagadish; Kustra, Rafal; Montpetit, Alexandre; Hudson, Thomas J; Gallinger, Steven; Campbell, Harry; Dunlop, Malcolm G
- Abstract
In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs in 2,057 Scottish cases and 2,111 controls. We then genotyped the five highest-ranked SNPs from the joint phase 1 and 2 analysis in 14,500 cases and 13,294 controls from seven populations, and identified a previously unreported association, rs3802842 on 11q23 (OR = 1.1; P = 5.8 x 10(-10)), showing population differences in risk. We also replicated and fine-mapped associations at 8q24 (rs7014346; OR = 1.19; P = 8.6 x 10(-26)) and 18q21 (rs4939827; OR = 1.2; P = 7.8 x 10(-28)). Risk was greater for rectal than for colon cancer for rs3802842 (P < 0.008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology.
- Publication
Nature genetics, 2008, Vol 40, Issue 5, p631
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.133