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- Title
Evolutionary plasticity of genetic interaction networks.
- Authors
Tischler, Julia; Lehner, Ben; Fraser, Andrew G
- Abstract
Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.
- Publication
Nature genetics, 2008, Vol 40, Issue 4, p390
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.114