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- Title
Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese.
- Authors
Akamatsu, Shusuke; Takata, Ryo; Haiman, Christopher A; Takahashi, Atsushi; Inoue, Takahiro; Kubo, Michiaki; Furihata, Mutsuo; Kamatani, Naoyuki; Inazawa, Johji; Chen, Gary K; Le Marchand, Loïc; Kolonel, Laurence N; Katoh, Takahiko; Yamano, Yuko; Yamakado, Minoru; Takahashi, Hiroyuki; Yamada, Hiroki; Egawa, Shin; Fujioka, Tomoaki; Henderson, Brian E; Habuchi, Tomonori; Ogawa, Osamu; Nakamura, Yusuke; Nakagawa, Hidewaki
- Abstract
We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 × 10(-4)) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 × 10(-10); FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 × 10(-8)) and 3p11.2 (rs2055109; P = 3.94 × 10(-8)). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 × 10(-7)). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
- Publication
Nature genetics, 2012, Vol 44, Issue 4, p426
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.1104