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- Title
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.
- Authors
Wu, Gang; Broniscer, Alberto; McEachron, Troy A; Lu, Charles; Paugh, Barbara S; Becksfort, Jared; Qu, Chunxu; Ding, Li; Huether, Robert; Parker, Matthew; Zhang, Junyuan; Gajjar, Amar; Dyer, Michael A; Mullighan, Charles G; Gilbertson, Richard J; Mardis, Elaine R; Wilson, Richard K; Downing, James R; Ellison, David W; Zhang, Jinghui; Baker, Suzanne J; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project
- Abstract
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration.
- Publication
Nature genetics, 2012, Vol 44, Issue 3, p251
- ISSN
1546-1718
- Publication type
Journal Article
- DOI
10.1038/ng.1102