We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Discovery of a natural thiamine adenine nucleotide.
- Authors
Bettendorff, Lucien; Wirtzfeld, Barbara; Makarchikov, Alexander F; Mazzucchelli, Gabriel; Frédérich, Michel; Gigliobianco, Tiziana; Gangolf, Marjorie; De Pauw, Edwin; Angenot, Luc; Wins, Pierre
- Abstract
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.
- Publication
Nature chemical biology, 2007, Vol 3, Issue 4, p211
- ISSN
1552-4450
- Publication type
Journal Article
- DOI
10.1038/nchembio867