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- Title
Significance of one-bead-one-compound combinational chemistry.
- Authors
Xiaoyuan Chen; Gambhir, Sanjiv S
- Abstract
One-bead-one-compound (OBOC) in combination with peptidomimetic and cell-based screening methods showed that these are effective tools for screening peptide and peptidomimetic ligands for target proteins. LLP2A was identified as a peptide ligand with binding affinity in the picomolar range against the integrin #x03B1;4#x03B2;1 has been developed. It has also been used to image #x03B1;4#x03B2;1-expressing tumors in living mice.
- Publication
Nature Chemical Biology, 2006, Vol 2, Issue 7, p351
- ISSN
1552-4450
- Publication type
Academic Journal
- DOI
10.1038/nchembio0706-351