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- Title
Expanding chemical biology of 2-oxoglutarate oxygenases.
- Authors
Loenarz, Christoph; Schofield, Christopher J
- Abstract
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.
- Publication
Nature chemical biology, 2008, Vol 4, Issue 3, p152
- ISSN
1552-4469
- Publication type
Journal Article
- DOI
10.1038/nchembio0308-152