We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical informatics and target identification in a zebrafish phenotypic screen.
- Authors
Laggner, Christian; Kokel, David; Setola, Vincent; Tolia, Alexandra; Lin, Henry; Irwin, John J; Keiser, Michael J; Cheung, Chung Yan J; Minor, Daniel L; Roth, Bryan L; Peterson, Randall T; Shoichet, Brian K
- Abstract
Target identification is a core challenge in chemical genetics. Here we use chemical similarity to computationally predict the targets of 586 compounds that were active in a zebrafish behavioral assay. Among 20 predictions tested, 11 compounds had activities ranging from 1 nM to 10,000 nM on the predicted targets. The roles of two of these targets were tested in the original zebrafish phenotype. Prediction of targets from chemotype is rapid and may be generally applicable.
- Publication
Nature Chemical Biology, 2012, Vol 8, Issue 2, p144
- ISSN
1552-4450
- Publication type
Academic Journal
- DOI
10.1038/nchembio.732