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- Title
Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells.
- Authors
Subramanian, Devaraj; Laketa, Vibor; Müller, Rainer; Tischer, Christian; Zarbakhsh, Sirus; Pepperkok, Rainer; Schultz, Carsten
- Abstract
Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phospholipid residing on early endosomes, where it is proposed to be involved in endosomal fusion. We synthesized membrane-permeant derivatives of PtdIns(3)P, including a caged version that is to our knowledge the first photoactivatable phosphoinositide derivative developed so far. In living cells, photoactivation of caged PtdIns(3)P induced rapid endosomal fusion in an EEA1-dependent fashion, thus providing in vivo evidence that PtdIns(3)P is a sufficient signal for driving this process.
- Publication
Nature chemical biology, 2010, Vol 6, Issue 5, p324
- ISSN
1552-4469
- Publication type
Journal Article
- DOI
10.1038/nchembio.348