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- Title
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.
- Authors
Hagel, Jillian M; Facchini, Peter J
- Abstract
Two previously undetected enzymes involved in morphine biosynthesis and unique among plants to opium poppy have been identified as non-heme dioxygenases, in contrast to the functionally analogous cytochrome P450s found in mammals. We used functional genomics to isolate thebaine 6-O-demethylase (T6ODM) and codeine O-demethylase (CODM), the only known 2-oxoglutarate/Fe(II)-dependent dioxygenases that catalyze O-demethylation. Virus-induced gene silencing of T6ODM and CODM in opium poppy efficiently blocked metabolism at thebaine and codeine, respectively.
- Publication
Nature chemical biology, 2010, Vol 6, Issue 4, p273
- ISSN
1552-4469
- Publication type
Journal Article
- DOI
10.1038/nchembio.317