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- Title
Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids.
- Authors
Xiangtian Long; Shenglou Deng; Mattner, Jochen; Zhuo Zang; Dapeng Zhou; McNary, Nathan; Goff, Randal D.; Teyton, Luc; Bendelac, Albert; Savage, Paul B.
- Abstract
Glycosphingolipids (GSLs) from the Sphingomonadaceae family of bacteria have been reported to be potent stimulators of natural killer T cells. These glycolipids include mono-, tri- and tetraglycosylceramides. Here we have prepared the GSL-1 to GSL-4 series of glycolipids and tested their abilities to stimulate natural killer T cells. Among these glycolipids, only GSL-1 (1) is a potent stimulator. Using a series of synthetic diglycosylceramides, we show that oligoglycosylceramides from Sphingomonadaceae are not effectively truncated to GSL-1 in lysosomes in antigen-presenting cells, possibly because the higher-order GSLs are poor substrates for lysosomal acyltransfer enzymes.
- Publication
Nature Chemical Biology, 2007, Vol 3, Issue 9, p559
- ISSN
1552-4450
- Publication type
Academic Journal
- DOI
10.1038/nchembio.2007.19