We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lys34 of translation elongation factor EF-P is hydroxylated by YfcM.
- Authors
Peil, Lauri; Starosta, Agata L; Virumäe, Kai; Atkinson, Gemma C; Tenson, Tanel; Remme, Jaanus; Wilson, Daniel N
- Abstract
Lys34 of the conserved translation elongation factor P (EF-P) is post-translationally lysinylated by YjeK and YjeA--a modification that is critical for bacterial virulence. Here we show that the currently accepted Escherichia coli EF-P modification pathway is incomplete and lacks a final hydroxylation step mediated by YfcM, an enzyme distinct from deoxyhypusine hydroxylase that catalyzes the final maturation step of eukaryotic initiation factor 5A, the eukaryotic EF-P homolog.
- Publication
Nature chemical biology, 2012, Vol 8, Issue 8, p695
- ISSN
1552-4469
- Publication type
Journal Article
- DOI
10.1038/nchembio.1001