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- Title
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.
- Authors
Stocker, Hugo; Radimerski, Thomas; Schindelholz, Benno; Wittwer, Franz; Belawat, Priyanka; Daram, Pierre; Breuer, Sebastian; Thomas, George; Hafen, Ernst
- Abstract
Understanding the mechanisms through which multicellular organisms regulate cell, organ and body growth is of relevance to developmental biology and to research on growth-related diseases such as cancer. Here we describe a new effector in growth control, the small GTPase Rheb (Ras homologue enriched in brain). Mutations in the Drosophila melanogaster Rheb gene were isolated as growth-inhibitors, whereas overexpression of Rheb promoted cell growth. Our genetic and biochemical analyses suggest that Rheb functions downstream of the tumour suppressors Tsc1 (tuberous sclerosis 1)-Tsc2 in the TOR (target of rapamycin) signalling pathway to control growth, and that a major effector of Rheb function is ribosomal S6 kinase (S6K).
- Publication
Nature cell biology, 2003, Vol 5, Issue 6, p559
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb995