We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover.
- Authors
Di Guglielmo, Gianni M; Le Roy, Christine; Goodfellow, Anne F; Wrana, Jeffrey L
- Abstract
Endocytosis of cell surface receptors is an important regulatory event in signal transduction. The transforming growth factor beta (TGF-beta) superfamily signals to the Smad pathway through heteromeric Ser-Thr kinase receptors that are rapidly internalized and then downregulated in a ubiquitin-dependent manner. Here we demonstrate that TGF-beta receptors internalize into both caveolin- and EEA1-positive vesicles and reside in both lipid raft and non-raft membrane domains. Clathrin-dependent internalization into the EEA1-positive endosome, where the Smad2 anchor SARA is enriched, promotes TGF-beta signalling. In contrast, the lipid raft-caveolar internalization pathway contains the Smad7-Smurf2 bound receptor and is required for rapid receptor turnover. Thus, segregation of TGF-beta receptors into distinct endocytic compartments regulates Smad activation and receptor turnover.
- Publication
Nature cell biology, 2003, Vol 5, Issue 5, p410
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb975