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- Title
Direct coupling of the cell cycle and cell death machinery by E2F.
- Authors
Nahle, Zaher; Polakoff, Julia; Davuluri, Ramana V; McCurrach, Mila E; Jacobson, Matthew D; Narita, Masashi; Zhang, Michael Q; Lazebnik, Yuri; Bar-Sagi, Dafna; Lowe, Scott W
- Abstract
Unrestrained E2F activity forces S phase entry and promotes apoptosis through p53-dependent and -independent mechanisms. Here, we show that deregulation of E2F by adenovirus E1A, loss of Rb or enforced E2F-1 expression results in the accumulation of caspase proenzymes through a direct transcriptional mechanism. Increased caspase levels seem to potentiate cell death in the presence of p53-generated signals that trigger caspase activation. Our results demonstrate that mitogenic oncogenes engage a tumour suppressor network that functions at multiple levels to efficiently induce cell death. The data also underscore how cell cycle progression can be coupled to the apoptotic machinery.
- Publication
Nature cell biology, 2002, Vol 4, Issue 11, p859
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb868