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- Title
The exocyst complex binds the small GTPase RalA to mediate filopodia formation.
- Authors
Sugihara, Kazuhiro; Asano, Shiro; Tanaka, Kenichi; Iwamatsu, Akihiro; Okawa, Katsuya; Ohta, Yasutaka
- Abstract
The Ras-related small GTPase RalA is involved in controlling actin cytoskeletal remodelling and vesicle transport in mammalian cells. We identified the mammalian homologue of Sec5, a subunit of the exocyst complex determining yeast cell polarity, as a specific binding partner for GTP-ligated RalA. Inhibition of RalA binding to Sec5 prevents filopod production by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) and by activated forms of RalA and Cdc42, signalling intermediates downstream of these inflammatory cytokines. We propose that the RalA-exocyst complex interaction integrates the secretory and cytoskeletal pathways.
- Publication
Nature cell biology, 2002, Vol 4, Issue 1, p73
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb720