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- Title
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair.
- Authors
Schwarz, Agatha; Ständer, Sonja; Berneburg, Mark; Böhm, Markus; Kulms, Dagmar; van Steeg, Harry; Grosse-Heitmeyer, Karin; Krutmann, Jean; Schwarz, Thomas
- Abstract
Induction of apoptosis of keratinocytes by ultraviolet (UV) radiation is a protective phenomenon relevant in limiting the survival of cells with irreparable DNA damage. Changes in UV-induced apoptosis may therefore have significant impact on photocarcinogenesis. We have found that the immunomodulatory cytokine IL-12 suppresses UV-mediated apoptosis of keratinocytes both in vitro and in vivo. IL-12 caused a remarkable reduction in UV-specific DNA lesions which was due to induction of DNA repair. In accordance with this, IL-12 induced the expression of particular components of the nucleotide-excision repair complex. Our results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines.
- Publication
Nature cell biology, 2002, Vol 4, Issue 1, p26
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb717