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- Title
The type I TGF-β receptor is covalently modified and regulated by sumoylation.
- Authors
Jong Seok Kang; Saunier, Elise F.; Akhurst, Rosemary J.; Derynck, Rik
- Abstract
Post-translational sumoylation, the covalent attachment of a small ubiquitin-like modifier (SUMO), regulates the functions of proteins engaged in diverse processes. Often associated with nuclear and perinuclear proteins, such as transcription factors, it is not known whether SUMO can conjugate to cell-surface receptors for growth factors to regulate their functions. Here we show that the type I transforming growth factor-β (TGF-β) receptor, TβRI, is sumoylated in response to TGF-β and that its sumoylation requires the kinase activities of both TβRI and the type II TGF-β receptor, TβRII. Sumoylation of TβRI enhances receptor function by facilitating the recruitment and phosphorylation of Smad3, consequently regulating TGF-β-induced transcription and growth inhibition. TβRI sumoylation modulates the dissemination of transformed cells in a mouse model of TβRI-stimulated metastasis. TβRI sumoylation therefore controls responsiveness to TGF-β, with implications for tumour progression. Sumoylation of cell-surface receptors may regulate other growth factor responses.
- Publication
Nature Cell Biology, 2008, Vol 10, Issue 6, p654
- ISSN
1465-7392
- Publication type
Academic Journal
- DOI
10.1038/ncb1728