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- Title
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.
- Authors
P., Pavan Kumar; Bischof, Oliver; Purbey, Prabhat Kumar; Notani, Dimple; Urlaub, Henning; Dejean, Anne; Galande, Sanjeev
- Abstract
The function of the subnuclear structure the promyelocytic leukaemia (PML) body is unclear largely because of the functional heterogeneity of its constituents. Here, we provide the evidence for a direct link between PML, higher-order chromatin organization and gene regulation. We show that PML physically and functionally interacts with the matrix attachment region (MAR)-binding protein, special AT-rich sequence binding protein 1 (SATB1) to organize the major histocompatibility complex (MHC) class I locus into distinct higher-order chromatin-loop structures. Interferon γ (IFNγ) treatment and silencing of either SATB1 or PML dynamically alter chromatin architecture, thus affecting the expression profile of a subset of MHC class I genes. Our studies identify PML and SATB1 as a regulatory complex that governs transcription by orchestrating dynamic chromatin-loop architecture.
- Publication
Nature Cell Biology, 2007, Vol 9, Issue 1, p45
- ISSN
1465-7392
- Publication type
Academic Journal
- DOI
10.1038/ncb1516