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- Title
APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.
- Authors
Reis, Alexandra; Chang, Heng-Yu; Levasseur, Mark; Jones, Keith T
- Abstract
Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.
- Publication
Nature cell biology, 2006, Vol 8, Issue 5, p539
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb1406