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- Title
GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution.
- Authors
Puthenveedu, Manojkumar A; Bachert, Collin; Puri, Sapna; Lanni, Frederick; Linstedt, Adam D
- Abstract
The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular requirements for, nor the purpose of, Golgi ribbon formation are known. Here, we demonstrate that ribbon formation is mediated by specific membrane-fusion events that occur during Golgi assembly, and require the Golgi proteins GM130 and GRASP65. Furthermore, these GM130 and GRASP65-dependent lateral cisternal-fusion reactions are necessary to achieve uniform distribution of enzymes in the Golgi ribbon. The membrane continuity created by ribbon formation facilitates optimal processing conditions in the biosynthetic pathway.
- Publication
Nature cell biology, 2006, Vol 8, Issue 3, p238
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb1366