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- Title
FoxM1 is required for execution of the mitotic programme and chromosome stability.
- Authors
Laoukili, Jamila; Kooistra, Matthijs R H; Brás, Alexandra; Kauw, Jos; Kerkhoven, Ron M; Morrison, Ashby; Clevers, Hans; Medema, René H
- Abstract
Transcriptional induction of cell-cycle regulatory proteins ensures proper timing of subsequent cell-cycle events. Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability. Loss of FoxM1 leads to pleiotropic cell-cycle defects, including a delay in G2, chromosome mis-segregation and frequent failure of cytokinesis. We show that transcriptional activation of cyclin B by FoxM1 is essential for timely mitotic entry, whereas CENP-F, another direct target of FoxM1 identified here, is essential for precise functioning of the mitotic spindle checkpoint. Thus, our data uncover a transcriptional cluster regulated by FoxM1 that is essential for proper mitotic progression.
- Publication
Nature cell biology, 2005, Vol 7, Issue 2, p126
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb1217