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Title
Under arrest in mitosis: Cdc20 dies twice.
Authors
Fry, Andrew M; Yamano, Hiroyuki
Abstract
The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.