We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A nuclear lamin is required for cytoplasmic organization and egg polarity in Drosophila.
- Authors
Guillemin, K; Williams, T; Krasnow, M A
- Abstract
Nuclear lamins are intermediate filaments that compose the nuclear lamina--the filamentous meshwork underlying the inner nuclear membrane--and are required for nuclear assembly, organization and maintenance. Here we present evidence that a nuclear lamin is also required for cytoplasmic organization in two highly polarized cell types. Zygotic loss-of-function mutations in the Drosophila gene encoding the principal lamin (Dm(0)) disrupt the directed outgrowth of cytoplasmic extensions from terminal cells of the tracheal system. Germline mutant clones disrupt dorsal-ventral polarity of the oocyte. In mutant oocytes, transcripts of the dorsal determinant Gurken, a transforming growth factor-alpha homologue, fail to localize properly around the anterodorsal surface of the oocyte nucleus; their ventral spread results in dorsalized eggs that resemble those of the classical dorsalizing mutations squid and fs(1)K10. The requirement of a nuclear lamin for cytoplasmic as well as nuclear organization has important implications for both the cellular functions of lamins and the pathogenesis of human diseases caused by lamin mutations.
- Publication
Nature cell biology, 2001, Vol 3, Issue 9, p848
- ISSN
1465-7392
- Publication type
Journal Article
- DOI
10.1038/ncb0901-848